Acetaminophen + Diphenhydramine + Phenylephrine

Fixed-dose combination

This page lists brands whose active-ingredient set is exactly the combination below. It is identity information only — a fixed-dose combination is not the same product as its single ingredients, and the brand names are not interchangeable across markets.

Not medical advice. Check the pack and the exact composition before comparing products; ask a pharmacist if unsure.

Active ingredients

Acetaminophen acetaminophen
Diphenhydramine diphenhydramine
Phenylephrine phenylephrine

Brands with this exact combination

Brand	Composition & strength	Manufacturer
Acetaminophen, Diphenhydramine HCl Phenylephrine HClUS	650 mg/20 mL / 25 mg/20 mL / 10 mg/20 mL / 10 mg/5,000 mg / 650 mg/5,000 mg / 25 mg/5,000 mg	Haleon US Holdings LLC
Acetaminophen, Diphenhydramine Hydrochloride, Phenylephrine HydrochlorideUS	500 mg / 25 mg / 10 mg / 650 mg/20 mL / 25 mg/20 mL / 10 mg/20 mL	Haleon US Holdings LLC
Acetaminophen, Diphenhydramine hydrochloride, and Phenylephrine hydrochlorideUS	25 mg / 10 mg / 650 mg / 325 mg/10 mL / 12.5 mg/10 mL / 5 mg/10 mL	Reckitt Benckiser LLC
ACETAMINOPHEN, DIPHENHYDRAMINE, PHENYLEPHRINEUS	650 mg / 25 mg / 10 mg	Chain Drug Manufacturing Assn
Theraflu Severe Cold relief NighttimeUS	powder Acetaminophen 500 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg powder Acetaminophen 650 mg/237 mL + Diphenhydramine 25 mg/237 mL + Phenylephrine 10 mg/237 mL powder Acetaminophen 650 mg + Diphenhydramine 25 mg liquid Acetaminophen 650 mg/30 mL + Diphenhydramine 25 mg/30 mL	Haleon US Holdings LLC
Allergy plus Sinus HeadacheUS	tablet ×4 Acetaminophen 325 mg + Diphenhydramine 12.5 mg + Phenylephrine 5 mg	Shield Pharmaceuticals Corp
Nighttime Severe Cold and CoughUS	powder ×2 Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg liquid Acetaminophen 650 mg/30 mL + Diphenhydramine 25 mg/30 mL + Phenylephrine 10 mg/30 mL	KROGER COMPANY
Acetaminophen, Diphenhydramine HCI, Phenylephrine HCIUS	650 mg/20 mL / 25 mg/20 mL / 10 mg/20 mL	Dolgencorp, Inc. (DOLLAR GENERAL & REXALL)
Acetaminophen, Diphenhydramine HCl and Phenylephrine HClUS	325 mg / 12.5 mg / 5 mg	ARMY AND AIR FORCE EXCHANGE SERVICE
Theraflu ExpressMax Nighttime Severe Cold and CoughUS	tablet Acetaminophen 325 mg + Diphenhydramine 12.5 mg + Phenylephrine 5 mg liquid Acetaminophen 650 mg/30 mL + Diphenhydramine 25 mg/30 mL + Phenylephrine 10 mg/30 mL	Haleon US Holdings LLC
SanaTos Severe Cold Relief NighttimeUS	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	Pharmadel LLC
Maximum Strength Nighttime Cold and FluUS	liquid Acetaminophen 650 mg/20 mL + Diphenhydramine 25 mg/20 mL + Phenylephrine 10 mg/20 mL	THE KROGER CO
Defensol D Blister PackUS	tablet Acetaminophen 325 mg + Diphenhydramine 12.5 mg + Phenylephrine 5 mg	Menper Distributors, Inc.
Acetaminophen, Diphenhydramine HCl, Phenylephrine HCIUS	325 mg / 12.5 mg / 5 mg	Menper Distributors, Inc.
Mucinex Childrens Night Time Multi-Symptom ColdUS	liquid Acetaminophen 325 mg/10 mL + Diphenhydramine 12.5 mg/10 mL + Phenylephrine 5 mg/10 mL	Reckitt Benckiser LLC
Vicks NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus CongestionUS	powder Acetaminophen 650 mg/5,000 mg + Diphenhydramine 25 mg/5,000 mg + Phenylephrine 10 mg/5,000 mg	Procter & Gamble Manufactura S de RL de CV
Night Time Severe Cold and Cough ReliefUS	liquid Acetaminophen 325 mg/15 mL + Diphenhydramine 12.5 mg/15 mL + Phenylephrine 5 mg/15 mL	Chain Drug Consortium, LLC
up and up nighttime flu and severe cold and coughUS	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	Target Corporation
Severe Allergy Plus Sinus HeadacheUS	tablet Acetaminophen 325 mg + Diphenhydramine 25 mg + Phenylephrine 5 mg	Wal-Mart Stores Inc
Childrens Delsym Cough Plus Cold Night TimeUS	liquid Acetaminophen 325 mg/10 mL + Diphenhydramine 12.5 mg/10 mL + Phenylephrine 5 mg/10 mL	Reckitt Benckiser LLC
Nighttime Wal Flu Severe Cold and CoughUS	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	WALGREEN CO.
Acetaminophen Diphenhydramine and Phenylephrine HydrochlorideUS	5 mg / 12.5 mg / 325 mg	Elysium Pharmaceuticals Ltd.
Severe Allergy And Sinus Headache Maximum StrengthUS	tablet Acetaminophen 325 mg + Diphenhydramine 25 mg + Phenylephrine 5 mg	CVS Pharmacy
Robitussin Severe Multi-Symptom Cough Cold Flu NighttimeUS	liquid Acetaminophen 650 mg/20 mL + Diphenhydramine 25 mg/20 mL + Phenylephrine 10 mg/20 mL	Haleon US Holdings LLC
THERAFLU POWERPODS NIGHTTIME SEVERE COLDUS	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	Haleon US Holdings LLC
Equate Childrens Multi symptom Cold NighttimeUS	liquid Acetaminophen 325 mg/10 mL + Diphenhydramine 12.5 mg/10 mL + Phenylephrine 5 mg/10 mL	Wal-Mart Stores, Inc.
dg health flu and severe cold and coughUS	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	Dolgencorp, LLC
Basic Care severe cold and coughUS	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	Amazon.com Services LLC
THERAFLU NIGHTTIME SEVERE COLD AND COUGHUS	powder Acetaminophen 650 mg/237 mL + Diphenhydramine 25 mg/237 mL + Phenylephrine 10 mg/237 mL	Haleon US Holdings LLC
Equate Flu and Severe Cold and CoughUS	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	Wal-Mart Stores Inc
Quality Choice Severe Cold and Cough NighttimeUS	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	Chain Drug Manufacturing Assn
Theraflu Severe Cold Relief Nighttime with Honey Elderberry FlavorUS	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	Haleon US Holdings LLC
CVS Childrens Nighttime Multi Symptom ColdUS	liquid Acetaminophen 325 mg/10 mL + Diphenhydramine 12.5 mg/10 mL + Phenylephrine 5 mg/10 mL	CVS PHARMACY
Allergy and Sinus HeadacheUS	tablet Acetaminophen 325 mg + Diphenhydramine 12.5 mg + Phenylephrine 5 mg	ARMY AND AIR FORCE EXCHANGE SERVICE
Severe Cold and Cough NighttimeUS	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	WinCo Foods, LLC
ACTIFED NOCHE ADVANCEMX	tablet Acetaminophen + Diphenhydramine + Phenylephrine	JANSSEN-CILAG, S.A. DE C.V.
THEALIV NOCHEMX	powder Acetaminophen + Diphenhydramine + Phenylephrine	Química y Farmacia, S.A. de C.V.
BENADRYL PE TOTAL REGULAR STRENGTHCA	tablet Acetaminophen 325 mg + Diphenhydramine 12.5 mg + Phenylephrine 5 mg	MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC
BENADRYL PE TOTAL EXTRA STRENGTHCA	tablet Acetaminophen 325 mg + Diphenhydramine 25 mg + Phenylephrine 5 mg	MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC
BENYLIN ALL-IN-ONE COLD AND FLU NIGHT PECA	tablet Acetaminophen 325 mg + Diphenhydramine 25 mg + Phenylephrine 5 mg	MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC
SINUTAB PE SINUS AND ALLERGYCA	tablet Acetaminophen 325 mg + Diphenhydramine 12.5 mg + Phenylephrine 5 mg	MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC
SUDAFED PE COLD AND COUGHCA	tablet Acetaminophen 325 mg + Diphenhydramine 12.5 mg + Phenylephrine 5 mg	MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC
EXTRA STRENGTH NEOCITRAN FLUCA	liquid Acetaminophen 21.666667 mg/1 mL + Diphenhydramine 0.833333 mg/1 mL + Phenylephrine 0.333333 mg/1 mL	NOVARTIS CONSUMER HEALTH CANADA INC.
BENADRYL ALLERGY SINUS HEADACHECA	tablet Acetaminophen 325 mg + Diphenhydramine 12.5 mg + Phenylephrine 5 mg	MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC
BENYLIN COLD AND SINUS NIGHTCA	tablet Acetaminophen 325 mg + Diphenhydramine 25 mg + Phenylephrine 5 mg	MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC
BENADRYL ALLERGY RAPID RELEASECA	tablet Acetaminophen 325 mg + Diphenhydramine 12.5 mg + Phenylephrine 5 mg	MCNEIL CONSUMER HEALTHCARE DIVISION OF JOHNSON & JOHNSON INC
EXTRA STRENGTH NEOCITRAN TOTAL SYMPTOM RELIEF - SUGAR FREECA	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	NOVARTIS CONSUMER HEALTH CANADA INC.
COMPLETE ONE COLD AND FLU PE NIGHTCA	tablet Acetaminophen 325 mg + Diphenhydramine 25 mg + Phenylephrine 5 mg	CELLCHEM PHARMACEUTICALS INC.
NIGHTTIME SYMPTOM RELIEF EXTRA STRENGTH FOR SYMPTOMS OF COLD AND COUGHCA	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	CELLCHEM PHARMACEUTICALS INC.
NEOCITRAN EXTRA STRENGTH TOTAL COLD NIGHTCA	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	HALEON CANADA ULC
NEOCITRAN TOTAL COLD NIGHTCA	powder Acetaminophen 500 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	HALEON CANADA ULC
EXTRA STRENGTH MULTI-SYMPTOM RELIEF SUGAR FREECA	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	CELLCHEM PHARMACEUTICALS INC.
EXTRA STRENGTH TOTAL SYMPTOM RELIEF SUGAR-FREECA	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	CELLCHEM PHARMACEUTICALS INC.
NIGHT TIME COLD & FLUCA	liquid Acetaminophen 32.5 mg/1 mL + Diphenhydramine 1.25 mg/1 mL + Phenylephrine 0.5 mg/1 mL	RECKITT BENCKISER (CANADA) INC
BUCKLEY'S COMPLETE COUGH, COLD & FLU NIGHTCA	tablet Acetaminophen 325 mg + Diphenhydramine 12.5 mg + Phenylephrine 5 mg	THE BUCKLEY'S COMPANY
NIGHTTIME COLDCA	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	LSL MEDPLUS INC
TOTAL COLD HOT LEMON RELIEFCA	powder Acetaminophen 500 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	CELLCHEM PHARMACEUTICALS INC.
TOTAL COLD NIGHTCA	powder Acetaminophen 500 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	CELLCHEM PHARMACEUTICALS INC.
SUPER STRENGTH COMPLETE COLDCA	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	CRLS
VICKS NYQUIL HOT REMEDYCA	powder Acetaminophen 650 mg + Diphenhydramine 25 mg + Phenylephrine 10 mg	PROCTER & GAMBLE INC

Same combination in other markets

No product with this combination is recorded in the other covered markets yet.

Only the main ingredient is the same — this is NOT the same fixed-dose combination. View the main ingredient

See warnings for these ingredients

Source & licence: built from the same regulator data as the ingredient pages (openFDA, dm+d, CIMA, COFEPRIS, PBS/TGA, Health Canada DPD, NHSA). Facts only; see the licence register.