Ivacaftor + Lumacaftor

Fixed-dose combination

This page lists brands whose active-ingredient set is exactly the combination below. It is identity information only — a fixed-dose combination is not the same product as its single ingredients, and the brand names are not interchangeable across markets.

Not medical advice. Check the pack and the exact composition before comparing products; ask a pharmacist if unsure.

Active ingredients

Ivacaftor ivacaftor
Lumacaftor lumacaftor

Brands with this exact combination

Brand	Composition & strength	Manufacturer
ORKAMBIAU CA ES EU GB US	powder ×9 Ivacaftor 125 mg + Lumacaftor 100 mg tablet ×5 Ivacaftor 125 mg + Lumacaftor 200 mg powder ×4 Ivacaftor 188 mg + Lumacaftor 150 mg powder ×4 Ivacaftor 94 mg + Lumacaftor 75 mg Other 1 compositions	Vertex Pharmaceuticals (Ireland) Limited
Lumacaftor 200mg / Ivacaftor 125mg tabletsAU ES GB	200 mg / 125 mg / 100 mg / 150 mg / 188 mg / 75 mg	Vertex Pharmaceuticals (Australia) Pty. Ltd.
lumacaftor and ivacaftorUS	75 mg / 94 mg / 100 mg / 125 mg / 150 mg / 188 mg	Vertex Pharmaceuticals Incorporated
Orkambi 100mg/125mg granules sachetsGB	powder Ivacaftor 125 mg + Lumacaftor 100 mg powder Ivacaftor 188 mg + Lumacaftor 150 mg powder Ivacaftor 94 mg + Lumacaftor 75 mg	Vertex Pharmaceuticals (Europe) Ltd
Lumacaftor 100mg / Ivacaftor 125mg granules sachetsGB	100 mg / 125 mg / 150 mg / 188 mg / 75 mg / 94 mg	Vertex Pharmaceuticals (Europe) Ltd
ORKAMBI 100/125 lumacaftor/ivacaftor 100mg/125mg granules sachetAU	powder Ivacaftor 125 mg + Lumacaftor 100 mg powder Ivacaftor 188 mg + Lumacaftor 150 mg powder Ivacaftor 94 mg + Lumacaftor 75 mg	Vertex Pharmaceuticals Australia Pty Ltd
ORKAMBI 100 mg/125 mg, granulés en sachetFR	powder Ivacaftor 125 mg + Lumacaftor 100 mg powder Ivacaftor 188 mg + Lumacaftor 150 mg powder Ivacaftor 94 mg + Lumacaftor 75 mg	VERTEX PHARMACEUTICALS (IRELAND)
ORKAMBI 200/125 lumacaftor/ivacaftor 200mg/125mg film-coated tablet blister packAU	tablet Ivacaftor 125 mg + Lumacaftor 100 mg tablet Ivacaftor 125 mg + Lumacaftor 200 mg	Vertex Pharmaceuticals Australia Pty Ltd
ORKAMBI 100 mg/125 mg, comprimé pelliculéFR	tablet Ivacaftor 125 mg + Lumacaftor 100 mg tablet Ivacaftor 125 mg + Lumacaftor 200 mg	VERTEX PHARMACEUTICALS (IRELAND)
lumacaftor + ivacaftor + ivacaftorAU	—	—

Same combination in other markets

These markets record products with the same active-ingredient combination. Identity only — not a recommendation that products are interchangeable.

CA · ORKAMBI · 5 products · record
ES · ORKAMBI · 5 products · record
GB · Orkambi 100mg/125mg granules sachets; ORKAMBI · 5 products · record
US · ORKAMBI · 5 products · record
AU · ORKAMBI · 5 products · record

See warnings for these ingredients

Source & licence: built from the same regulator data as the ingredient pages (openFDA, dm+d, CIMA, COFEPRIS, PBS/TGA, Health Canada DPD, NHSA). Facts only; see the licence register.